According to statistics, more than 50% of women will develop at least one urinary tract infection (UTI) throughout their lifetime. Antibiotics are touted as the most common and effective treatment for UTI. However, their side effects are well-known and better avoided, so natural treatments like D-mannose are receiving more and more attention.
But, before you jump on the D-mannose wagon, you owe it to yourself to find out more about it. It is vital that you understand what this potential treatment is, how it works, how safe it is, and how you should use it. We will cover everything you need to know in the following lines.
What Is D-mannose?
D-mannose is a simple carbohydrate or sugar occurring naturally in many fruits (cranberries, oranges, apples, peaches, etc) but also in some human body cells. Other names for it are D-manosa, Mannose, D-Mannopyranose, Carubinose, and Seminose.
Its chemical formula is C6H12O6. Its molar mass is 180.16 g/mol. It has excellent solubility in water and acetic acid. The data is common to glucose as well. What makes mannose different? While glucose is used as a sweetener, mannose is a common basic ingredient in supplement product lines.
Why Are People Taking It and What Is It Good for?
Treats CDG Syndrome
D-mannose has been used to treat type 1 CDG syndrome. carbohydrate-deficient glycoprotein syndrome type 1b. The disease is transmitted genetically. Those who have it lose protein through their intestines. Mannose seems to slow down the loss of protein, improve liver function, help with bleeding disorders, and regulate blood sugar.
Mannose Acts as a Prebiotic
Mannose has also been labeled as an effective prebiotic, able to feed and help good bacteria thrive and overcome bad bacteria. A 2012 study revealed that mannose is able to restore microflora composition, induces pro- and anti-inflammatory cytokines expression, and has immunostimulating properties.
According to a 2018 study, supplementation with it in high-fat-diet-fed mice prevented weight gain, lowered adiposity, reduced liver steatosis, increased endurance, maximized O2 consumption, and improved glucose tolerance. When mannose was stopped, the mice started gaining weight again.
May Treat Yeast Infections
Cranberry juice is often promoted as a natural treatment for yeast infections and it is rich in mannose. A recent study explored further uses of mannose against Candida and found that mannose-binding lectin reduces the growth of yeast cells and drives existing formations inert.
Can Successfully Replace Antibiotics as a Treatment for UTI
Since 80% of UTI cases are bacteria-related, it makes sense to use a prebiotic to treat them. Recently, more and more scientists have been exploring the possibility of using this fruit sugar to treat UTI. Preliminary data suggests that the bacteria considered responsible for UTIs bind to mannose molecules instead of sticking to the bladder walls and is, thus, eliminated from the body.
Will D-Mannose Really Treat UTI?
Cranberry juice has long been used as a natural remedy for urinary tract infections. Mannose could be responsible for its effectiveness. Most urinary tract infections (90%) are caused by E. Coli. The bacteria enter the urinary tract, attach themselves to the tract lining, and thrive, causing the infection.
Apparently, in the presence of D-mannose, the bacteria no longer bind to the urinary tract cells. Instead, they bind to the monosaccharide molecules and are eliminated through urine. Although research on mannose as a treatment for UTI is in its early stages, several have already confirmed its effectiveness.
One study evaluated the effects of D-mannose on 308 subjects with a history of UTI. The results showed that D-mannose was approximately as effective as nitrofurantoin (an antibiotic) in treating UTIs over a period of 6 months.
Another study compared D-mannose to trimethoprim/sulfamethoxazole (antibiotic). It involved 60 female subjects and showed that the sugar considerably reduced UTI symptoms and was more effective than antibiotics at preventing recurrences.
Scientists studied the effects of D-mannose on 43 female patients diagnosed with acute UTI. Most subjects saw considerable improvement in symptoms.
Researchers from Washington University School of Medicine (St. Louis) confirmed that D-mannose acts as a molecular decoy, reducing the number of E. coli gut bacteria and, thus, has the potential to treat UTI. Therefore, it is no doubt that D mannose has the potential to treat urinary tract infections.
However, in order to obtain the desired results, it is important that you take the necessary dosage and in adequate form. Otherwise, your efforts could be in vain.
How to Use D-mannose
More and more products based on D-mannose reach the market every day. When choosing between them, you should take three important aspects into account:
- Your goal: it is one thing to treat an active infection and a completely different thing to prevent infections.
- Dosage: find out what dose you will need and what taking it would mean with the specific product you are considering
- Product form and composition: you may have to choose between pills and powders. You may need several servings a day. Some products contain many fillers and additives that could have side effects. Find out all the details and assess their impact on your daily routine before choosing one D-mannose product over another.
Generally, the recommended dosage of d-mannose for preventing UTIs is of 2g daily, taken in two servings.
To treat an active infection, you will need approximately 3g daily. There are two options available:
1) Two servings of 1.5g a day for the first three days and then one serving daily for the following ten days
2) Three 1g servings a day for 14 days.
Is D-Mannose Safe?
Mannose-based supplements are generally safe. However, depending on your health condition, you may want to consult with your physician before taking them. Supplementation may cause loose stools or mild diarrhea in some rare cases.
Since it is ultimately a form of sugar, diabetes sufferers should consult their doctor and monitor their blood sugar levels closely. Otherwise, you have nothing to worry about, especially if you choose your product carefully and stick to the recommended dosage.
Have You Tried D-Mannose or Queen V utmi?
If you have taken d-Mannose we would love to find out more about your experience with it, so don’t hesitate to share it in a comment below! If you are considering supplementation with mannose for the first time, consider trying our Queen V utmi antioxidant and urinary tract support formula. It has helped thousands of users and will surely help you too!